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Power of child’s stem cells to Fight incurable diseases
Power of child’s stem cells to Fight incurable diseases
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2025/08/05:Featured in Corning’s white paper, our innovative manufacturing technology for SQ-SHED
S-Quatre is engaged in the research and development of novel cell-based therapies (regenerative medicine products) utilizing SQ-SHED, a proprietary stem cells from human exfoliated deciduous teeth (SHED), with the aim of developing new treatments for pediatric and rare diseases for which no effective therapies currently exist.

In collaboration with Corning Life Sciences (“Corning”), we are advancing the development of next-generation large-scale manufacturing method for commercial use and have successfully established a proprietary process optimized for the characteristics of SQ-SHED. This platform also holds potential for broader applications across a variety of cell-based products beyond SQ-SHED.

In recognition of this technological achievement, our initiative was featured in Corning’s latest white paper, "Producing MSC-derived Cell Therapies from Isolation to Large-scale Expansion: a Journey of Workflows, Technologies, and Case Studies." The full white paper is available on Corning’s official website.

Furthermore, in preparation for late-stage clinical trials, we are currently collaborating with Nipro Corporation to develop a formulation manufacturing process based on this platform. We remain committed to driving innovation and advancing development to deliver SQ-SHED-based therapies to patients worldwide as swiftly as possible.


White Paper by Corning
https://www.corning.com/worldwide/en/products/life-sciences/resources/webforms/msc-whitepaper.html
 
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Our Science
Science

Aiming for the World's First Cell Therapy Using SHED

Research of regenerative medicine using various types of cells has been actively performed around the world. We focused on SHED “stem cells from a child’s tooth” and are strenuously conducting the research and development to realize a new cell therapeutics for various intractable diseases.

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Our Platform
Platform

S-Quatre® – Stable Manufacturing and Supply System of Cell Banks for Cell Therapeutics

Practical application of cell therapeutics needs to stably procure donor tissue sources, manufacture cell banks, and supply them. We established a stable manufacturing and supply system of SHED banks named S-Quatre® by our own technology and network, composing a platform of the development of our cell therapeutics.